NFL Fantasy 2025 Week 12 Start ‘Em, Sit ‘Em Defenses

Looking for some fantasy football defense advice for Week 12? You’re in the right place! Start ‘Em, Sit ‘Em is here to guide you through those tough lineup decisions. We’re not just going to tell you to start obvious players like Christian McCaffrey — that’s too easy. Instead, we’re diving into more complex situations to help you set the best lineup possible. And if you don’t see a specific player mentioned here, be sure to check out the latest NFL Fantasy lineup rankings.

Let’s dive into some defenses you might want to start this week:

Seattle Seahawks (7-3) AT Tennessee Titans (1-9):
Seattle didn’t have the best fantasy outing last week, but facing the Rams was always going to be tough. However, let’s not forget that they’ve been the highest-scoring fantasy defense so far this season. This week, they take on the Titans, who have given up the most fantasy points to opposing defenses this year. With issues in sacks and turnovers, Seattle has a good chance to put up big numbers against Tennessee.

Green Bay Packers (6-3-1) VS. Minnesota Vikings (4-6):
While the Packers are strong on the field, they haven’t always been consistent in fantasy. However, this week they face the Vikings, who have allowed the fourth-most fantasy points to opposing defenses. With a high sack rate and interceptions thrown by J.J. McCarthy, the Packers defense, led by Micah Parsons, could have a strong showing.

Las Vegas Raiders (2-8) VS. Cleveland Browns (2-8):
The Browns have been a good matchup for fantasy defenses all season, no matter the quarterback. This week, Shedeur Sanders will make his first start. While talented, Sanders has struggled with sacks and lack of practice time with the first team. Against a confident Las Vegas defense, there’s potential for a big fantasy performance.

When setting your lineup for Week 12, consider these matchups and the potential for your defense to score big points. Happy fantasy managing!